Alcohol interferes with the brain’s communication pathways and can affect the way the brain operates. Drinking over a prolonged period or excessively in a single occasion can damage the heart. Heavy drinking can also lead to cirrhosis of the liver and inflammation. Alcohol causes the pancreas to produce toxic substances that can eventually lead to pancreatitis, a dangerous inflammation and swelling of the blood vessels in the pancreas which prevents proper digestion. Drinking heavily can increase your risk of developing certain cancers. Drinking heavily can weaken your immune system, making your body a much more susceptible for disease.